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Prof Richard G Wise 


Dr Richard Wise
Position:Professor and FMRI Director, CUBRIC

Telephone:+44(0)29 208 70358
Fax:+44(0)29 208 70339
Extension:70358

Richard joined CUBRIC as FMRI Director in October 2006 from Oxford University (FMRIB Centre) where he led the methodological development of human pharmacological FMRI studies, particularly in the field of pain and analgesia. This work has led Richard to develop his research agenda aimed at improving the interpretability of FMRI data in demanding applications, such as drug studies. In 2005 he won a Medical Research Council Career Development Award to support his work initially in Oxford and now in Cardiff. This programme aims to investigate the physiological basis of FMRI measurements and neurovascular coupling using the recently implemented combined techniques of simultaneous EEG-FMRI.

Richard’s current research interests include:

  • The development of quantitative FMRI methods for human pharmacological imaging studies
  • The tracking of drug action e.g. analgesics, over time in the human brain
  • Investigation of empirical neurovascular coupling in humans using simultaneous EEG-FMRI applied to evoked and ongoing brain activity
  • The physiology underlying blood oxygen level dependent FMRI image contrast
  • Imaging the networks engaged in the control of breathing in humans

Selected Publications

Wise RG, Pattinson KT, Bulte DP, Chiarelli PA, Mayhew SD, Balanos GM, O'connor DF, Pragnell TR, Robbins PA, Tracey I, Jezzard P. Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. J Cereb Blood Flow Metab. 2007 Apr 4; [Epub ahead of print]

 

Wise RG, Ide K, Poulin MJ, Tracey I. Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. Neuroimage. 2004 Apr;21(4):1652-64.

 

Wise RG, Williams P, Tracey I. Using fMRI to quantify the time dependence of remifentanil analgesia in the human brain. Neuropsychopharmacology. 2004 Mar;29(3):626-35.

 

Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I. Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage. 2002 Aug;16(4):999-1014.

 

Research Projects

Grants on which Richard Wise is Principal Investigator:

  • Dec 2005 – Nov 2009. MRC Career Development Award (held at Cardiff University).
    Pharmacological neuroimaging: Assessing FMRI as a biomarker of changes in neuronal activity using combined EEG and FMRI.
    Total value £472864, including Fellow’s salary, 4 years of research costs and full time research assistant’s salary.
  • Jun 2006 – July 2007. Pfizer Ltd (held at Oxford University).
    Assessing measures of brain activity in pharmacological FMRI.
    Total value £70,000. The grant funds a post-doctoral research scientist for one year supervised by Dr Wise.

Grants on which Richard Wise is a collaborator:

  • 2005-2007. Association of Anaesthetists of Great Britain and Ireland (held at Oxford University).
    Imaging the neural correlates of respiratory control.
    Grant holder: Dr Jaideep Pandit.
    £23,760 in research costs
  • Jan 2006 – Dec 2007. International Anaesthesia Research Society (held at Oxford University).
    Investigation of pharmacological modulation of respiratory control using FMRI.
    Principal Investigator: Dr Kyle Pattinson.
    $79,632 in research and support costs.
  • Jan 2006 – Dec 2008. MRC Clincial Training Fellowship (held at Oxford University).
    Investigation of pharmacological modulation of respiratory control using functional magnetic resonance imaging.
    Principal Investigator: Dr Kyle Pattinson
    Richard Wise is acting as a DPhil supervisor to Dr Pattinson under this project.
  • Jun 2006- May 2008. GlaxoSmithKline (held at Oxford University).
    Developing pharmacokinetic/pharmacodynamic measures in human FMRI.
    Principal Investigator: Prof Irene Tracey.
    £200,000 in research and staff costs to support a post-doctoral scientist for 2 years.

Research Students

My current research students are based at Oxford University, studying for Dphil degrees.

Dr Ana Diukova (Research Associate - Combined EEG-fMRI).

Mr Stephen Mayhew (FMRIB Centre, Department of Clinical Neurology, Oxford University).

Dr Kyle Pattinson (FMRIB Centre, Department of Clinical Neurology, Oxford University).